Author

Elizabeth Abraham

Temple UniversityORCID 0000-0002-2143-6597Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Organism:human· 4 Assay:scRNA-seq· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Conchi EstarásiD· 5 shared Mikel Zubillaga· 4 shared Naiara AkizuiD· 4 shared Thomas RouléiD· 4 shared Eleonora StronatiiD· 3 shared Olivia M. Pericak· 3 shared Aidan DouglasiD· 2 shared Emily MegilliD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersDevelopmental Biology

Conchi EstarásORCID

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5 papers

Recent·Most cited

YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast

Elizabeth Abraham, Thomas Roulé, Aidan Douglas, Emily Megill, Olivia M. Pericak, Jordan Howe, Carmen Choya-Foces, Joanne F. Garbincius, Henry M. Cohen, Paula Roig-Flórez, Mikel Zubillaga, Mark Andrake, Seonhee Kim, John W. Elrod, Naiara Akizu, Conchi Estarás

The paper identifies YAP1 and QSER1 as key regulators of developmental signaling pathways in the mammalian epiblast, showing their role in maintaining pluripotency and preventing excessive differentiation.

EMBO Reports · Mar 26, 2026Peer-reviewedDevelopmental Biology

YAP levels regulate anteroposterior elongation of hESC-derived gastruloids

Elizabeth Abraham, Thomas Roulé, Olivia M. Pericak, Mikel Zubillaga, Naiara Akizu, Conchi Estarás

This study shows that YAP activity levels control the elongation of h3D-gastruloids by affecting the establishment of anterior and posterior domains.

bioRxiv · Dec 2, 2025 · PreprintDevelopmental Biology

A Retinoic Acid:YAP1 signaling axis controls atrial lineage commitment

Elizabeth Abraham, Aleksandra S. Kostina, Brett D. Volmert, Thomas Roulé, Ling Huang, Jingting Yu, April E. Williams, Emily Megill, Aidan Douglas, Olivia M. Pericak, Alex Morris, Eleonora Stronati, Arantza Larrinaga-Zamanillo, Raquel Fueyo, Mikel Zubillaga, , Conchi Estarás

The paper identifies YAP1 as a non-canonical effector of RA signaling essential for atrial lineage commitment in cardiac progenitor cells.

Cell Reports · May 1, 2025Peer-reviewedDevelopmental Biology

Single-cell RNA sequencing of mutant whole mouse embryos: from the epiblast to the end of gastrulation

Elizabeth Abraham, Mikel Zubillaga, Thomas Roulé, Eleonora Stronati, Naiara Akizu, Conchi Estarás

This paper establishes a pipeline for high-quality single-cell and nuclei suspensions of gastrulating mouse embryos to enable single-cell sequencing analysis of mutant embryos.

Journal of Visualized Experiments · Jun 14, 2024Peer-reviewedDevelopmental Biology

YAP1 Regulates the Self-organized Fate Patterning of hESCs-Derived Gastruloids

Servando Giráldez, Eleonora Stronati, Ling Huang, Hui-Ting Hsu, Elizabeth Abraham, Kathy A. Jones, Conchi Estarás

This study shows YAP1 is essential for proper germ layer patterning in hESCs-derived gastruloids by regulating NODAL signaling and repressing mesoendodermal differentiation.

bioRxiv · Mar 12, 2021 · PreprintDevelopmental Biology