Conchi Estarás

The paper identifies YAP1 and QSER1 as key regulators of developmental signaling pathways in the mammalian epiblast, showing their role in maintaining pluripotency and preventing excessive differentiation.

This study shows that YAP activity levels control the elongation of h3D-gastruloids by affecting the establishment of anterior and posterior domains.

The paper identifies YAP1 as a non-canonical effector of RA signaling essential for atrial lineage commitment in cardiac progenitor cells.

This paper establishes a pipeline for high-quality single-cell and nuclei suspensions of gastrulating mouse embryos to enable single-cell sequencing analysis of mutant embryos.

This study shows YAP1 is essential for proper germ layer patterning in hESCs-derived gastruloids by regulating NODAL signaling and repressing mesoendodermal differentiation.