Victor V. Lobanenkov

This study shows that BORIS, a CTCF paralog, promotes ovarian cancer by altering 3D genome organization and transcriptional programs through chromatin remodeling.

This study shows that incomplete silencing of human BORIS in a humanized mouse model leads to increased cancer susceptibility through ectopic gene activation in somatic cells.

This study shows that CTCF binding is influenced by the epigenetic state of the N-terminal nucleosome and its orientation relative to CTCF motifs, affecting chromatin architecture.

The paper shows that CTCF and BORIS work together in spermatogenesis, with their combined loss causing infertility due to defective meiosis and gene expression.