Dharmendra Nath Bhatt

The CTCF Paralog BORIS Contributes to the Ovarian Cancer Transcriptional Program by Relaxing CTCF-mediated 3D Genome Organization

This study shows that BORIS, a CTCF paralog, promotes ovarian cancer by altering 3D genome organization and transcriptional programs through chromatin remodeling.

Incomplete developmental silencing of cancer-testis antigen BORIS in humanized mouse model promotes cancer susceptibility

This study shows that incomplete silencing of human BORIS in a humanized mouse model leads to increased cancer susceptibility through ectopic gene activation in somatic cells.

CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation.

This study shows that CTCF binding is influenced by the epigenetic state of the N-terminal nucleosome and its orientation relative to CTCF motifs, affecting chromatin architecture.