Arnaud Zaldumbide

Totum-448 reduces hepatic steatosis and inflammation in diet-induced MASLD mice without affecting body weight or microbiota.

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

The paper introduces the R-package CONQUER to analyze type 2 diabetes risk loci by integrating genomic and epigenomic data, revealing tissue-shared effects on metabolic and HLA pathways.