Author

Zhen Dong

La Jolla Institute for ImmunologyORCID 0000-0001-6706-3899Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Anjana RaoiD· 2 shared Geoffrey J. FaulkneriD· 2 shared Hugo SepúlvedaiD· 2 shared Leo J. Arteaga-Vazquez· 2 shared Samuel A. MyersiD· 2 shared Aurélie Modat· 1 shared Caitlin Brown· 1 shared Chad Blouin· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersMolecular Biology

Anjana RaoORCID

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2 papers

Recent·Most cited

Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedMar 28, 2025

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

Hugo Sepúlveda, Xiang Li, Leo J. Arteaga-Vazquez…·Anjana Rao

This study shows that OGT inhibits TET activity, preventing DNA demethylation and transposable element expression in heterochromatin.

25 citationstop 2%

mouseDNA methylation

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Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewedJan 3, 2025

A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia

Zhen Dong, Hugo Sepúlveda, Leo J. Arteaga-Vazquez…·Anjana Rao

This study shows that mutant ASXL1 proteins disrupt heterochromatin integrity in clonal hematopoiesis and CMML by reducing H3K9me2/3 and H2AK119Ub, leading to increased transposable element expression.

13 citationstop 2%

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