Karen H. Ashe

This study shows that Aβ*56 levels are higher in Alzheimer's dementia compared to mild cognitive impairment and no cognitive impairment, and are linked to cognitive decline independent of amyloid plaques.

The paper demonstrates that Aβ*56 is present in brain extracts enriched for extracellular proteins from Tg2576 mice, suggesting its presence in the extracellular space.

The paper characterizes A{beta}*56, a non-fibrillar A{beta} oligomer in Tg2576 mice, showing it correlates with age-related memory loss and is SDS-stable.

The paper develops a FRET-based biosensor platform to screen small molecules targeting toxic tau oligomers, identifying MK-886 as a compound that disrupts tau oligomers and reduces cytotoxicity.