David Dale Thomas

The paper develops a FRET assay to directly quantify the IHM state of human β-cardiac myosin and shows how mutations and perturbations affect its stability.

The paper identifies a SIRT6 variant enriched in centenarians that improves genome stability through enhanced mADPr activity and interaction with Lamin A.

The paper uses TR-FRET to directly measure the correlation between the interacting-heads motif (IHM) and super-relaxed state (SRX) in myosin, finding that SRX is more stabilized by mavacamten than IHM.

The paper identifies potent small molecules that inhibit toxic alpha-synuclein oligomers and reduce cell death in SH-SY5Y cells using a FRET-based biosensor platform.

The paper develops a FRET-based biosensor platform to screen small molecules targeting toxic tau oligomers, identifying MK-886 as a compound that disrupts tau oligomers and reduces cytotoxicity.