Paul A. Yushkevich

This paper introduces a computational framework for automated anatomical segmentation and cortical reconstruction in high-resolution postmortem infant MRI, showing improved performance across diverse datasets.

The paper examines subcortical and limbic volume associations with cortical thinning and neurodegenerative pathologies in postmortem brain MRI data from multiple disease groups.

The paper develops a harmonized segmentation protocol for hippocampal subfields in MRI, improving cross-study comparisons and understanding of subfield structure and function.

The paper characterizes hippocampal subfield border variability using postmortem MRI and histology, finding consistent subfield appearance/disappearance orders and no clear diagnosis-related differences.

The paper presents a harmonized segmentation protocol for the hippocampal tail in high-resolution MRI, improving cross-study comparability through standardized definitions and consensus-based guidelines.

This paper develops a multi-modality MRI segmentation model to improve robustness of medial temporal lobe subregion segmentation in poor-quality images.

The paper develops a segmentation protocol for anterior medial temporal lobe regions and integrates it into an automated approach to improve imaging biomarkers for neurodegenerative diseases.

The paper surveys QC practices for hippocampal subfield segmentation in MRI and provides recommendations to improve reliability and reporting.

The paper compares medial temporal lobe atrophy patterns in early-onset and late-onset amnestic Alzheimer's disease, finding similar atrophy levels but differences in specific subregions.

This paper compares cytoarchitectonic delineations of medial temporal lobe subregions by four neuroanatomists, finding higher agreement in some areas and less in others.

This paper develops an automated framework for analyzing low-field MRI scans to detect biomarkers of severe brain swelling in cerebral malaria.

This study uses joint ex vivo MRI and histology to identify distinct iron-rich gliosis patterns in FTLD-Tau and FTLD-TDP, distinguishing them from other neurodegenerative conditions.

This study creates 3D maps of neurofibrillary tangle burden in the human medial temporal lobe using ex vivo MRI and dense histology, revealing variation along the anterior-posterior axis and widespread NFT distribution.

The paper examines the link between episodic memory and temporal discounting in older adults, finding that better memory correlates with less discounting of delayed rewards.

TAPAS is an automated thresholding algorithm for segmenting brain lesions in MS using probability maps, reducing error and bias compared to manual and group-level thresholding.