Yamei Deng

Long-term immune reprogramming of classical monocytes with altered ontogeny mediates enhanced lung injury in sepsis survivors

The paper shows that sepsis reprograms monocytes into a pro-inflammatory state and shifts their lineage toward neutrophil-like cells, increasing lung injury risk in survivors.

Ficd loss rescues motor impairments and reverses oligodendrocyte maturation deficits in a mouse model of spinocerebellar ataxia type 3

This study shows that loss of FICD rescues motor impairments and reverses oligodendrocyte maturation deficits in a SCA3 mouse model by restoring ER homeostasis and myelination.

Analysis of isobaric quantitative proteomic data using TMT-Integrator and FragPipe computational platform

The paper introduces TMT-Integrator, a tool for analyzing isobaric proteomic data, showing improved performance in protein and phosphorylation site quantification compared to existing tools.

TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and -independent mitophagy

This study shows TRAF6 regulates glucose homeostasis via mitophagy in islets, with both Parkin-dependent and -independent pathways involved.

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

This study identifies LONP1's role in mitochondrial protein folding and shows its impact on beta cell survival and hyperglycemia in type 2 diabetes.

MSFragger-DDA+ Enhances Peptide Identification Sensitivity with Full Isolation Window Search

MSFragger-DDA+ improves peptide identification sensitivity by searching the full isolation window and handling co-fragmented peptides, enhancing proteomics data analysis.

Analysis and visualization of quantitative proteomics data using FragPipe-Analyst

FragPipe-Analyst provides an R shiny web server and R package for downstream analysis and visualization of quantitative proteomics data from FragPipe.