Author

Vaibhav Sidarala

University of MichiganORCID 0000-0002-8010-3418Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

Jie ZhuiD· 4 shared Scott A. SoleimanpouriD· 4 shared Emily M. WalkeriD· 3 shared Emma C. ReckiD· 3 shared Alexey I. NesvizhskiiiD· 2 shared Anne C. LietzkeiD· 2 shared Ava M. Stendahl· 2 shared Belle A. Henry-Kanarek· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMolecular Biology

Jie ZhuORCID

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Author profile →

4 papers

Recent·Most cited

TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and -independent mitophagy

Elena Levi-D’Ancona, Emily M. Walker, Jie Zhu, Yamei Deng, Vaibhav Sidarala, Ava M. Stendahl, Emma C. Reck, Belle A. Henry-Kanarek, Anne C. Lietzke, Biaoxin Chai, Mabelle B. Pasmooij, Dre L. Hubers, Venkatesha Basrur, Sankar Ghosh, Linsey Stiles, , Scott A. Soleimanpour

This study shows TRAF6 regulates glucose homeostasis via mitophagy in islets, with both Parkin-dependent and -independent pathways involved.

Science Advances · Oct 8, 2025Peer-reviewedMolecular Biology

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

Jin Li, Yamei Deng, Marie Gasser, Jie Zhu, Emily M. Walker, Vaibhav Sidarala, Emma C. Reck, Dre L. Hubers, Mabelle B. Pasmooij, Chun-Shik Shin, Khushdeep Bandesh, Eftyhmios Motakis, Siddhi Nargund, Romy Kursawe, Venkatesha Basrur, , Scott A. Soleimanpour

This study identifies LONP1's role in mitochondrial protein folding and shows its impact on beta cell survival and hyperglycemia in type 2 diabetes.

Nature Metabolism · Jul 21, 2025Peer-reviewedCell Biology

Limitations in PPAR-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells

Anne C. Lietzke, Emily M. Walker, Elizabeth J. Bealer, Kelly M. Crumley, Jessica King, Ava M. Stendahl, Jie Zhu, Gemma L. Pearson, Elena Levi-D’Ancona, Belle A. Henry-Kanarek, Rebecca K. Davidson, Jin Li, Emma C. Reck, Yifei Wu, Manikanta Arnipalli, , Scott A. Soleimanpour

This study identifies PPAR-dependent mitochondrial programming as a limiting factor in the differentiation of human stem cell-derived β cells and shows that PPAR agonists can enhance β cell formation and function.

bioRxiv · Jul 26, 2024 · PreprintDevelopmental Biology

The human disease gene CLEC16A encodes an intrinsically disordered protein region required for mitochondrial quality control

Morgan A. Gingerich, Xueying Liu, Biaoxin Chai, Gemma L. Pearson, Michael P. Vincent, Tracy Stromer, Jie Zhu, Vaibhav Sidarala, Aaron Renberg, Debashish Sahu, Daniel J. Klionsky, Santiago D. Schnell, Scott A. Soleimanpour

This study identifies an intrinsically disordered protein region in CLEC16A critical for mitochondrial quality control and diabetes prevention.

bioRxiv · Sep 3, 2021 · PreprintMolecular Biology