Cunming Duan

This study develops synthetic PAPP-A inhibitors that modulate IGF signaling in vitro and in vivo, showing efficacy comparable to natural inhibitors.

This study identifies Stc2a as a hypoxia-induced factor that inhibits IGF signaling to prioritize survival over growth in zebrafish.

The paper shows that Sox10 is required for systemic calcium uptake necessary for bone mineralization, through regulation of Stc1a production by neural crest cells.

This study identifies Stc1a as a Ca2+-regulated switch that controls epithelial cell quiescence-proliferation balance and calcium uptake in zebrafish.

The paper identifies Papp-aa as a [Ca2+]-regulated molecular switch that links IGF signaling to ionocyte reactivation and bone calcification in zebrafish.

This study identifies Trpv6 as a regulator of epithelial cell quiescence by maintaining Ca2+ influx and suppressing growth factor signaling.