Irena Selicharová

Synthetic inhibitors of pregnancy-associated plasma protein-A regulate IGF-1 signaling in vitro and in vivo

This study develops synthetic PAPP-A inhibitors that modulate IGF signaling in vitro and in vivo, showing efficacy comparable to natural inhibitors.

Antagonistic insulin mimetics lock the insulin receptor in an alternative apo-state

This paper reveals how insulin mimetics stabilize the insulin receptor in a novel apo-state that prevents activation by blocking signal transduction.