Keith Mathieson

A biomimetic deep encoder for auditory restoration by cortical stimulation

This paper introduces Braincodec, a deep encoder that improves sound transmission via cortical stimulation, achieving high-fidelity sound reconstruction and matching non-implanted mice in sound discrimination.

Electrodeposited Biocompatible Coatings for 3D Electrodes on Retinal Prostheses

The paper develops biocompatible coatings for 3D electrodes on retinal prostheses using electrodeposition and photolithography to protect gold surfaces while preserving functionality.

Titanium and platinum coatings reduce inflammation induced by gold on subretinal prosthesis

This study shows that gold coatings on subretinal implants cause retinal inflammation and neuronal loss, while platinum and titanium coatings reduce these effects, enabling better visual resolution implants.

Chronically implantable μLED arrays for optogenetic cortical surface stimulation in mice

This paper introduces a chronically implantable μLED array for optogenetic cortical stimulation in mice, demonstrating long-term stability and effective neuronal responses.

Depth-resolved fiber photometry of amyloid plaque signals in freely behaving Alzheimer's disease mice

This paper introduces a depth-resolved fiber photometry method to monitor amyloid plaque signals in freely behaving Alzheimer's disease mice, showing depth-specific fluorescent signal increases in diseased mice.

Amorphous silicon resistors enable smaller pixels in photovoltaic retinal prosthesis

The paper develops doped amorphous silicon resistors for photovoltaic retinal implants, enabling smaller pixel sizes and improved electric field contrast without reducing photoresponsivity.

Enhancing Prosthetic Vision by Upgrade of a Subretinal Photovoltaic Implant in situ

This study upgrades a subretinal photovoltaic implant in rats, improving visual acuity from 100m to 28m pixels.

3D electronic implants in subretinal space: long-term follow-up in rodents

This study evaluates long-term biocompatibility and performance of 3D honeycomb-shaped subretinal implants in rats, showing improved stimulation thresholds compared to flat designs.

In vivo optogenetics using a Utah Optrode Array with enhanced light output and spatial selectivity

This paper develops and tests an optimized Utah Optrode Array for in vivo optogenetics in non-human primates, showing improved light delivery and spatial selectivity.

An Optrode Array for Spatiotemporally Precise Large-Scale Optogenetic Stimulation of Deep Cortical Layers in Non-human Primates

The paper introduces an optrode array for precise optogenetic stimulation of deep cortical layers in non-human primates, demonstrating its ability to activate neurons in specific or widespread regions.

Three-dimensional electro-neural interfaces electroplated on subretinal prostheses

This paper develops 3D electroplated structures for subretinal prostheses to improve electric field penetration and stimulation efficiency in retinal implants.

Cellular integration with a subretinal honeycomb-shaped prosthesis

The paper demonstrates that retinal neurons migrate into honeycomb-shaped wells of a subretinal prosthesis, enabling selective stimulation of second-order neurons without affecting electrical excitability or causing additional glial stress.

Simultaneous electrophysiological recording and fiber photometry in freely behaving mice

This paper combines electrophysiological recording and fiber photometry to simultaneously monitor sub-second neural activity and cell-type-specific calcium transients in freely behaving mice.

A multi-site MicroLED Optrode Array for Neural Interfacing

The paper introduces a multi-site MicroLED Optrode Array for neural interfacing capable of optogenetic excitation in large mammals.