This study identifies high-quality neoantigens in follicular lymphoma patients using WES and RNA-Seq, and initiates a clinical trial of personalized neoantigen vaccines combined with PD-1 blockade.

Blood Advances · May 7, 2024Peer-reviewedGenetic & Genomic Medicine

Ultra Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma

Felicia Gomez, Bryan A. Fisk, Joshua F. McMichael, Matthew Mosior, Jennifer Ann Foltz, Zachary L. Skidmore, Eric James Duncavage, Christopher A. Miller, Haley Abel, Yi-Shan Li, David A. Russler‐Germain, Kilannin Krysiak, Marcus P. Watkins, Cody A. Ramirez, Alina D. Schmidt, , Obi L. Griffith

This study uses ultra-deep exome sequencing to identify recurrent mutations in classical Hodgkin lymphoma HRS cells, demonstrating its utility for analyzing genomic variants in large patient cohorts.

Cancer Research Communications · Nov 1, 2023Peer-reviewedGenetic & Genomic Medicine

Determining subpopulation methylation profiles from bisulfite sequencing data of heterogeneous samples using DXM

Jerry Fong, Jacob R. Gardner, Jared M. Andrews, Amanda F. Cashen, Jacqueline E. Payton, Kilian Q. Weinberger, John R. Edwards

DXM deconvolves methylation profiles of subpopulations from heterogeneous bisulfite sequencing data, showing improved performance over existing methods and linking methylation to relapse in DLBCLs.

Nucleic Acids Research · Jun 4, 2021Peer-reviewedBioinformatics