Author

Onyinyechi C. Onyeador

Washington University in St. LouisORCID 0000-0002-5665-5706Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Cody A. RamireziD· 2 shared Ethan D. McClainiD· 2 shared Jasreet HundaliD· 2 shared Malachi GriffithiD· 2 shared Michelle Becker‐HapakiD· 2 shared Obi L. GriffithiD· 2 shared Susanna KiwalaiD· 2 shared Todd A. FehnigeriD· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Cody A. RamirezORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Neoantigen Landscape Supports Feasibility of Personalized Cancer Vaccine for Follicular Lymphoma

Cody A. Ramirez, Michelle Becker‐Hapak, Kartik Singhal, David A. Russler‐Germain, Felix E. Frenkel, Erica Kay Barnell, Ethan D. McClain, Sweta Desai, Timothy Schappe, Onyinyechi C. Onyeador, Olga M. Kudryashova, Vladislav Belousov, Alexander Bagaev, Elena Ocheredko, Susanna Kiwala, , Todd A. Fehniger

This study identifies high-quality neoantigens in follicular lymphoma patients using WES and RNA-Seq, and initiates a clinical trial of personalized neoantigen vaccines combined with PD-1 blockade.

Blood Advances · May 7, 2024Peer-reviewedGenetic & Genomic Medicine

Computational prediction of MHC anchor locations guide neoantigen identification and prioritization

Huiming Xia, Joshua F. McMichael, Michelle Becker‐Hapak, Onyinyechi C. Onyeador, Rico Buchli, Ethan D. McClain, Patrick Pence, Suangson Supabphol, Megan M. Richters, Anamika Basu, Cody A. Ramirez, Cristina Puig-Saus, Kelsy C. Cotto, Sharon L. Freshour, Jasreet Hundal, , Malachi Griffith

The paper predicts MHC anchor positions for 328 HLA alleles and shows that incorporating these improves neoantigen identification by correcting misclassified candidates in tumor samples.

Science Immunology · Apr 7, 2023Peer-reviewedBioinformatics