Lars Kolbowski

The paper audits error control in twelve crosslinking mass spectrometry pipelines using ground-truth designs, finding some pipelines exceed false discovery rates by up to 29-fold.

xiView is a platform for analyzing and visualizing Crosslinking Mass Spectrometry data, supporting multiple datasets and using coordinated visualization techniques.

The paper introduces an MS3-trigger algorithm that improves the sensitivity and specificity of MS3-based crosslinker identification in crosslinking mass spectrometry.

The paper evaluates MS-cleavable crosslinkers, finding that improved peptide backbone fragmentation, not mass resolution, is the main advantage of DSSO.

The paper analyzes UVPD fragmentation of tryptic peptides at 213 nm, finding that sequence coverage and fragment intensity correlate with precursor charge density and that aromatic amino acids enhance fragmentation.