Author

Albert J.R. Heck

Utrecht University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:protein folding & dynamics· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

A.F. Maarten Altelaar· 1 shared Alfredo Cabrera-Orefice· 1 shared Andrew KelleriD· 1 shared Anna Akhmanova· 1 shared B.C. do AmaraliD· 1 shared Benjamin P. Bouchet· 1 shared Benjamin T. Goult· 1 shared Claudio IacobucciiD· 1 shared

Activity by Year

2016-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCell Biology

A.F. Maarten Altelaar

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Author profile →

3 papers

Recent·Most cited

A community audit of error control in crosslinking mass spectrometry

Lutz Fischer, B.C. do Amaral, Micha Johannes Birklbauer, James E. Bruce, Paulo C. Carvalho, Robert J. Chalkley, Milan Avila Clasen, Viktoria Dorfer, Fabio Cesar Gozzo, Albert J.R. Heck, Michael R. Hoopmann, Claudio Iacobucci, Andrew Keller, Lars Kolbowski, Swantje Lenz, , Juri Rappsilber

The paper audits error control in twelve crosslinking mass spectrometry pipelines using ground-truth designs, finding some pipelines exceed false discovery rates by up to 29-fold.

bioRxiv · Apr 27, 2025 · PreprintBioinformatics

Selective cross-linking of coinciding protein assemblies by in-gel cross-linking mass-spectrometry

Johannes F Hevler, Marie V Lukassen, Alfredo Cabrera-Orefice, Susanne Arnold, Matti F Pronker, Vojtech Franc, Albert J.R. Heck

This paper introduces IGX-MS, a cross-linking workflow combining blue native PAGE and in-gel cross-linking mass spectrometry, to analyze co-occurring protein complexes with reduced artificial over-length cross-links.

bioRxiv · Jul 10, 2020Biochemistry

Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions.

Benjamin P. Bouchet, Rosemarie E. Gough, Dieudonnee van de Willige, York-Christoph Ammon, Harm Post, Guillaume Jacquemet, A.F. Maarten Altelaar, Albert J.R. Heck, Benjamin T. Goult, Anna Akhmanova

This study identifies the talin-KANK1 interaction as essential for recruiting microtubule-stabilizing complexes to focal adhesions, linking actin and microtubule dynamics.

bioRxiv · May 24, 2016Cell Biology