Andrew Keller

The paper audits error control in twelve crosslinking mass spectrometry pipelines using ground-truth designs, finding some pipelines exceed false discovery rates by up to 29-fold.

The paper uses quantitative cross-linking and mass spectrometry data to cluster cross-links by their conformational state preferences, providing insights into protein conformational plasticity across different biological contexts.

The paper uses qXL-MS to study interactome changes during heat stress, finding RNA-binding proteins show significant interactome shifts, suggesting RNA acts as a temperature sensor.

The paper analyzes cross-links and dead-end peptides from XL-MS data to infer conformational changes in proteins between different conditions.

The paper uses cross-linking to study mitochondrial interactome changes in aging mouse muscle, finding age-related shifts in protein interactions linked to functional decline.

The paper uses AlphaFold2 to predict structures for 65,484 human protein interactions, identifying high confidence models and disease-related mutations.

The paper uses XL-MS and iqPIR to compare mitochondrial protein interactions in healthy and failing murine hearts, identifying structural changes in metabolic machinery.

The paper uses isotope-labeled crosslinkers to analyze protein interactions and posttranslational modifications in Diaphorina citri across life stages, revealing developmental changes in chromatin structure.

This study identifies SS-31 interacting proteins in mitochondria using chemical cross-linking and mass spectrometry, revealing their roles in ATP production and 2-oxoglutarate metabolism.