Author
University of British ColumbiaORCID 0000-0001-6819-7071Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Jenkin Tsui, Naila Adam, Woongcheol Choi…·Nicholas A. Walton
Serval is a modular framework for decoding spatial transcriptomics data that introduces Cosine, a method improving transcript recovery and correlation with expression references.
Mirela Andronescu, Alexander Adrian-Hamazaki, Damian Yap…·Samuel A. J. R. Aparicio
This paper develops a framework to analyze chromosomal mutational patterns at single-cell resolution, revealing drug-induced mutational signatures in human tissues.
Hoa Tran, Gurdeep Singh, Hakwoo Lee…·Samuel A. J. R. Aparicio
This study shows that somatic copy number mutations (CNA) influence metastatic fitness in breast cancer by mediating transcriptional changes and affecting clone survival in different sites.
Marc J. Williams, Michael U. J. Oliphant, Vinci Au…·Samuel A. J. R. Aparicio
The paper analyzes copy number alterations in breast epithelial cells from BRCA mutation carriers and wildtype individuals, finding lineage-specific CNAs that mirror cancer genomes.
Farhia Kabeer, Hoa Tran, Mirela Andronescu…·Samuel A. J. R. Aparicio
The paper identifies genomic and non-genomic contributions to drug resistance in triple negative breast cancer using single cell transcriptomics and copy number data.