Author
BC Cancer AgencyORCID 0000-0002-2422-3108Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
6 papers
Recent·Most cited
Mirela Andronescu, Alexander Adrian-Hamazaki, Damian Yap…·Samuel A. J. R. Aparicio
This paper develops a framework to analyze chromosomal mutational patterns at single-cell resolution, revealing drug-induced mutational signatures in human tissues.
Farhia Kabeer, Matteo Lepur, Branden J. Lynch…·Andrew J. L. Roth
cfClone, a Bayesian model, deconvolves cfDNA whole-genome sequencing using scWGS-derived haplotype-specific clone copy-number profiles to estimate tumour fraction, clonal prevalence, and flag missed clones.
Elena Zaikova, Damian Yap, Armaghan Sarvar…·Samuel A. J. R. Aparicio
The paper investigates the mutational signature of CX5461, a photosensitiser, when combined with UVA light, showing increased SNV burden only in co-exposed cells.
Hoa Tran, Gurdeep Singh, Hakwoo Lee…·Samuel A. J. R. Aparicio
This study shows that somatic copy number mutations (CNA) influence metastatic fitness in breast cancer by mediating transcriptional changes and affecting clone survival in different sites.
Farhia Kabeer, Hoa Tran, Mirela Andronescu…·Samuel A. J. R. Aparicio
The paper identifies genomic and non-genomic contributions to drug resistance in triple negative breast cancer using single cell transcriptomics and copy number data.
Adam J. Widman, Minita J. Shah, Amanda Frydendahl…·Dan Avi Landau
This paper introduces MRD-EDGE, a machine learning platform for ultrasensitive ctDNA detection in plasma WGS, showing improved sensitivity and broader applicability for MRD monitoring.