Damian Yap

G4SCOPE identifies sequence features and epigenetic contexts of chromatin G-quadruplexes

G4SCOPE predicts chromatin G-quadruplex occupancy from DNA sequence, revealing epigenetic differences in BRCA1 and BRCA2 deficient cells.

Chromosomal mutational signatures of DNA damaging agents at single cell resolution

This paper develops a framework to analyze chromosomal mutational patterns at single-cell resolution, revealing drug-induced mutational signatures in human tissues.

The UV potentiated mutational signature of clinical stage G-quadruplex binder CX5461.

The paper investigates the mutational signature of CX5461, a photosensitiser, when combined with UVA light, showing increased SNV burden only in co-exposed cells.

Somatic copy number mutations contribute to fitness in transplantation models of spontaneous human breast cancer metastasis

This study shows that somatic copy number mutations (CNA) influence metastatic fitness in breast cancer by mediating transcriptional changes and affecting clone survival in different sites.

EIF4A3 associated splicing and nonsense mediated decay defined by a systems analysis with novel small molecule inhibitors

The paper defines eIF4A3's role in splicing and NMD through a systems analysis using novel small molecule inhibitors and shows its link to cell cycle regulation.