Michael Naumann

Discovery of chromatin-based determinants of azacytidine and decitabine anti-cancer activity

This study identifies DNA hypomethylation, not DNA damage, as the primary mechanism of azacytidine and decitabine anti-cancer activity, linking it to chromatin regulators like USP48.

The deubiquitinating enzyme CYLD impairs NF-κB- and STAT1-dependent macrophage intrinsic immunity to Staphylococcus aureus

This study shows that CYLD impairs macrophage immunity to S. aureus by inhibiting STAT1 and NF-κB pathways, contributing to disease severity in atopic dermatitis.

ALPK1 And TIFA Dependent Innate Immune Response Triggered By The Helicobacter Pylori Type IV Secretion System

The paper identifies ALPK1 and TIFA as key components of an innate immune response triggered by H. pylori's T4SS, independent of CagA translocation.