Author

Simin Xu

Nanjing University of Chinese MedicineORCID 0000-0001-6839-9642Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Jing ShiiD· 2 shared Liqiao Xu· 2 shared Wei LiniD· 2 shared Yu FengiD· 2 shared Zonghang Ye· 2 shared Aijia Wen· 1 shared Fei Gao· 1 shared Guoping ZhaoiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Jing ShiORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 2, 2025

Structural insight into the transcription activation mechanism of the phage Mor/C family activators

Jing Shi, Zonghang Ye, Yirong Huang…·Wei Lin

This study presents cryo-EM structures of Mor-TAC and C-TAC complexes, revealing a tetrameric binding mode and interactions with RNAP, elucidating the transcription activation mechanism of phage Mor/C family activators.

DOI 10.1101/2025.05.02.651988

E. colicryo-EM

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MicrobiologyNature CommunicationsPeer-reviewedFeb 13, 2025

Structural insights into transcription regulation of the global virulence factor PhoP from Mycobacterium tuberculosis

Jing Shi, Zhenzhen Feng, Qian Song…·Wei Lin

This study determines cryo-EM structures of PhoP-dependent transcription complexes in Mtb to elucidate its dual role as activator and repressor in stress adaptation.

6 citations

cryo-EMexperimental assay

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