Liqiao Xu

AlphaFold 3-powered discovery of phage proteins that inhibit bacterial transcription

This study uses AlphaFold 3 to identify and characterize phage proteins that inhibit bacterial transcription, revealing novel mechanisms of action.

Structural and mechanistic insights into bacterial hydrazine biosynthesis

This study determines the crystal structures of bacterial hydrazine synthetases and elucidates their mechanism, enabling the expansion of hydrazine biosynthesis through novel enzyme discovery and chemoenzymatic synthesis.

Molecular mechanism of the key dormancy regulator DosR-dependent transcription activation in Mycobacterium tuberculosis

This study determines the cryo-EM structure of the DosR-dependent transcriptional activation complex in Mtb and identifies its molecular mechanism for dormancy regulation.

Structural insight into the transcription activation mechanism of the phage Mor/C family activators

This study presents cryo-EM structures of Mor-TAC and C-TAC complexes, revealing a tetrameric binding mode and interactions with RNAP, elucidating the transcription activation mechanism of phage Mor/C family activators.

Structural insights into transcription regulation of the global virulence factor PhoP from Mycobacterium tuberculosis

This study determines cryo-EM structures of PhoP-dependent transcription complexes in Mtb to elucidate its dual role as activator and repressor in stress adaptation.