Wei Lin

Molecular mechanism of the key dormancy regulator DosR-dependent transcription activation in Mycobacterium tuberculosis

This study determines the cryo-EM structure of the DosR-dependent transcriptional activation complex in Mtb and identifies its molecular mechanism for dormancy regulation.

Structural insight into the transcription activation mechanism of the phage Mor/C family activators

This study presents cryo-EM structures of Mor-TAC and C-TAC complexes, revealing a tetrameric binding mode and interactions with RNAP, elucidating the transcription activation mechanism of phage Mor/C family activators.

Structural insights into transcription regulation of the global virulence factor PhoP from Mycobacterium tuberculosis

This study determines cryo-EM structures of PhoP-dependent transcription complexes in Mtb to elucidate its dual role as activator and repressor in stress adaptation.

Structural basis of ECF-sigma-factor-dependent transcription initiation.

This study reports crystal structures of ECF-sigma-factor-dependent transcription initiation complexes in Mycobacterium tuberculosis, revealing conserved interactions with RNAP and promoter DNA.

Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3)

This paper reports the cryo-EM structure of Mycobacterium tuberculosis RNAP holoenzyme bound to fidaxomicin, revealing its unique binding site and mechanism of transcription inhibition.

Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition

This study reports crystal structures of Mycobacterium tuberculosis RNA polymerase with and without antituberculosis drugs, revealing a new class of inhibitors and their binding mechanisms.