David M.J. Lilley

The paper identifies millions of self-cleaving ribozymes in humans and other species, revealing a much larger ribozyme-ome than previously thought and their potential roles in gene regulation and biotechnology.

The paper identifies three families of bacterial tRNA-like RNAs through structural and genetic analysis, linking one family to sporulation control in Clostridioides difficile.

The paper shows short RNAs can form complex structures like icosahedrons and filaments, expanding the known RNA quaternary structures and supporting RNA-based self-assembly in an RNA world.

This study shows ANKLE1 is a tension-stimulated endonuclease that cleaves DNA branchpoints under high tension, aiding in resolving interchromosomal bridges during mitosis.

The paper determines the structure and catalytic mechanism of two new HDV ribozymes from a nematode and a virus, revealing a unique Lewis acid mechanism distinct from other ribozymes.