Jeroen E. J. Guikema

AbSolution enables integrated analysis of sequence-derived features in immune repertoires across datasets and conditions.

This study shows AID regulates proliferation and ABC-type transcriptional programs in DLBCL by affecting MYC/E2F pathways and IRF4/NF-κB activity.

This study shows that levamisole suppresses B-cell proliferation and antibody production, offering mechanistic insights into its therapeutic use in idiopathic nephrotic syndrome.

This study compares clone identification methods for B-cell repertoires and finds Shannon entropy to be the most robust diversity index, with alignment-free methods preferred for shorter reads.