Siyuan Luo

This study examines the epigenetic effects of prolonged fasting in humans, finding changes in DNA methylation and epigenetic aging clocks linked to metabolic responses.

The paper evaluates five single-cell RNA sequencing pipelines using Omnibenchmark, highlighting differences in parameter implementation across tools.

This paper provides a framework for selecting and understanding validation metrics for subpopulation detection in single-cell and spatial omics data, developing new metrics and implementing them in a Bioconductor package.

The paper benchmarks computational methods for analyzing scATAC-seq data, finding that SnapATAC and SnapATAC2 outperform other methods in cell-type discrimination and scalability.

This study shows that loss of H3K9me3 in adult mice leads to premature aging, characterized by reduced lifespan, frailty, and accelerated epigenetic aging.

This study compares clone identification methods for B-cell repertoires and finds Shannon entropy to be the most robust diversity index, with alignment-free methods preferred for shorter reads.