Aldo Jongejan

Single-cell characterization of 3D CLL spheroid model that recapitulates lymph node microenvironment-driven phenotypes and in vivo drug responses to ibrutinib

The paper uses a 3D CLL spheroid model to study how lymph node microenvironmental signals influence CLL cell phenotypes and drug responses to ibrutinib.

Systematic evaluation of robustness to cell type mismatch of deconvolution methods for spatial transcriptomics data

This study evaluates how deconvolution methods for spatial transcriptomics data perform when cell types are missing from reference datasets, finding that performance decreases with the number of missing cell types.

AbSolution: interactive exploration of sequence-derived features in AIRR-seq repertoires

AbSolution enables integrated analysis of sequence-derived features in immune repertoires across datasets and conditions.

Infiltrative classical monocyte-derived and SPP1 lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritis

This paper identifies specific macrophage subsets in ANCA-associated glomerulonephritis that drive inflammation and fibrosis, suggesting therapeutic targets.

Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation

The paper examines microglia nodules in multiple sclerosis and finds they are associated with higher lesion load and specific gene expression changes compared to stroke.

Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevity

The paper identifies atracurium as an FDA-approved compound that extends lifespan and healthspan in C. elegans by activating the FOXO/DAF-16 longevity pathway through neuromuscular acetylcholine receptor inhibition.

Core Circadian Clock Genes Per1 and Per2 regulate the Rhythm in Photoreceptor Outer Segment Phagocytosis

This study shows that Per1 and Per2 are required for the daily rhythm of photoreceptor outer segment phagocytosis, with the RPE driving this process transcriptionally.

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

This study shows glycine supplementation extends C. elegans lifespan and alters gene expression, with effects dependent on the methionine cycle.