Yasukazu Daigaku

The paper investigates the role of DNA polymerase in human DNA replication and mutagenesis based on strand and replication timing.

The paper identifies hypoacetylation-defined enhancers in luminal breast cancer cells and links them to subtype-specific gene regulation and patient classification.

This study shows that NELF-C loss disrupts Pol II transcription termination and causes transcription-replication conflicts in colorectal cancer.

The paper uses Pu-seq to map DNA polymerase usage in human cells, revealing Polε synthesizes the leading strand and Pol contributes to lagging strand synthesis, and links transcription to polymerase uncoupling and chromosomal instability.