Peter A. Koopman

The paper identifies HNF1B dysfunction as a cause of Mayer-Rokitansky-Küster-Hauser syndrome using genomic analysis and mouse models.

The paper investigates the role of Mmd2 and related PAQR genes in mouse sex determination, finding no essential function despite their expression in testis development.

The paper generates a transgenic mouse model expressing human SRY to study its role in sex determination and DSD, identifying functional domains and mutations.

This study identifies a genetic interaction between Pkd1 and Wnt5a in controlling lymphatic vascular morphogenesis in mice, showing mutual suppression of lymphatic defects.

This study shows that Sox17 expression in cardiac progenitor cells biases their fate toward the endocardium and regulates myocardium development through NOTCH signaling in mice.

This paper shows that Nr5a1 suppression during fetal development optimizes ovarian development by fine-tuning Notch signaling, using mouse models with altered Nr5a1 expression.

The paper tests TALEN specificity by knocking out three H2A.B genes with a single TALEN pair, demonstrating high specificity for this multi-copy gene family.