Drew Endy

This paper introduces a simple method to track bacterial growth in droplets over 12 hours, revealing growth rate heterogeneity not apparent in batch assays.

This study quantifies gene expression changes in Staphylococcus epidermidis under varying glucose and temperature conditions, identifying glucose-responsive genes and a heat-shock response similar to related species.

The paper evaluates the capacity of a cell-free system to remake life-essential functions and finds that only 19 of 23 tested components can be remade, with some functions remaining incomplete.

The paper demonstrates that minicells can express engineered plasmids and support substantial peptide bond formation, suggesting potential for lineage-agnostic organism engineering.

The paper establishes standardized methods and reference materials for measuring wood-degrading fungi growth to enable reproducible and scalable bioproduction.

The paper analyzes regulatory elements in yeast to understand their interactions and develops methods to estimate their contributions to gene expression.

The paper demonstrates genome annotation completeness for bacteriophage oX174 by synthesizing mutant genomes and showing no new genes are encoded beyond known essential and cryptic ORFs.

This paper designs synthetic genetic codes that hinder evolution by preventing point mutations from altering protein function, showing reduced evolutionary rates in simulated and experimental systems.

The paper develops abstract functions to control cell border curvature, endpoint reliability, and texture through physical cell properties, enabling engineered biological patterns.

This paper develops a system for autonomous control of heterologous gene expression in batch cultures using endogenous promoters and recombinase switches.

The paper quantifies translation initiation in E. coli from all 64 codons, finding that 46 codons can initiate translation at levels up to 2% relative to AUG.

The paper shows that red fluorescent proteins can bias cell density measurements by increasing optical density at 600 nm, suggesting measuring at 700 nm avoids this issue.