Namrita Dhillon

The paper uses long-read sequencing to study how nucleosome positioning affects isoform expression by analyzing chromatin and RNA in yeast.

The paper introduces SMAdd-seq, a method to profile chromatin accessibility using small molecule intercalation and nanopore sequencing, and demonstrates its application in yeast.

Benchmarking six long-read RNA-seq protocol-platform combinations and 14 tools across human, mouse, and manatee shows read length and accuracy drive isoform detection, depth drives quantification.

This study shows that heterochromatin stably silences weak regulatory elements but not housekeeping genes, with Sir1 playing a limiting role in silencing.

The paper reports a SARS-CoV-2 lineage with mutations from known variants of concern that is rejected by sequence repositories due to a deletion, suggesting underestimation of its frequency.

The paper quantifies the threshold of histone acetylation required to switch silent chromatin to active state in budding yeast.

The paper analyzes regulatory elements in yeast to understand their interactions and develops methods to estimate their contributions to gene expression.

This study shows that removing tRNA genes from a chromosome does not broadly disrupt chromosome folding but affects local nucleosome positioning and SMC protein binding, as well as centromere and heterochromatin clustering.