Xiaoyu Qian

The paper evaluates the contribution of expression, splicing, and protein QTL in blood to SNP-based heritability and polygenic prediction across 27 traits, finding they capture significant portions of genetic variation.

The paper identifies tissue-informative DNA methylation sites in ALS using targeted sequencing and machine learning, showing accurate prediction of disease status and progression.

This study investigates the function of the ALS risk variant GGNBP2 in Drosophila motor neurons, showing it regulates autophagy and synaptic development.