Yangming Wang

MuSIC predicts cross-species RBP-RNA interactions using evolutionary conservation and label smoothing, outperforming existing methods and quantifying variant effects on binding.

POND-seq enables non-destructive RNA and RBP-RNA interactome monitoring in live cells, revealing transcriptomic changes and RBP function.

This paper introduces REDDIT, an RNA editing-based reporter system to monitor promoter activity without requiring reporter proteins, showing it works for coding, noncoding, and miRNA genes and can be adapted for in vivo imaging.

The paper introduces a method to monitor lncRNA promoter activity and track stem cell differentiation using a GRIT strategy in mouse ESCs.

This study shows that an acidic microenvironment, caused by lactate accumulation, promotes pluripotency in mouse and human ESCs through multiple mechanisms involving histone modification, mRNA stability, and microRNA regulation.