David Salcedo-Tacuma

The paper maps the TRiC/CCT interactome in mouse photoreceptors and identifies its role in energy metabolism and neurodegeneration.

This study shows that a hyperactive 20S proteasome in C. elegans improves degradation of misfolded proteins, reduces oxidative damage, and extends lifespan without relying on known proteostasis pathways.

ProEnd identifies and catalogs HbYX motif-containing proteins across diverse organisms, revealing their evolutionary conservation and potential role in proteasome interactions.