Author

Emily R. Sechrest

West Virginia UniversityORCID 0000-0002-4541-9492Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Wen‐Tao DengiD· 3 shared Tongju Guan· 2 shared Becky Chen· 1 shared Brooke A. BrothersiD· 1 shared Celine BrooksiD· 1 shared David M. SmithiD· 1 shared David Salcedo-TacumaiD· 1 shared Douglas R. KolsoniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

Wen‐Tao DengORCID

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3 papers

Recent·Most cited

Mapping the chaperonin TRiC/CCT interactome in mouse photoreceptors reveals functional significance for energy metabolism

Celine Brooks, David Salcedo-Tacuma, Isabella Mascari, Mark Eminhizer, Tuan Ngo, Douglas R. Kolson, Emily R. Sechrest, Tongju Guan, Neil Billington, Wen‐Tao Deng, David M. Smith, Jianhai Du, Nikolai P. Skiba, Maxim Sokolov

The paper maps the TRiC/CCT interactome in mouse photoreceptors and identifies its role in energy metabolism and neurodegeneration.

PLoS ONE · Jul 29, 2026Peer-reviewedBiochemistry

Molecular Mechanisms Limiting the Therapeutic Window of AAV Gene Therapy in Mouse Models of Blue Cone Monochromacy

Brooke A. Brothers, Emily R. Sechrest, Li Ma, Madyson E. Ashcraft, Tongju Guan, Robert J. Barbera, Marion E. Cahill, Lee M. Shaw, Becky Chen, Wolfgang Baehr, Gangqing Hu, Peter Stoilov, Wen‐Tao Deng

This study evaluates AAV gene therapy in BCM mouse models, finding that older mutant mice show reduced treatment efficacy due to decreased transduction and cone degeneration, while specific promoters remain active.

bioRxiv · Feb 14, 2025 · PreprintMolecular Biology

P23H rhodopsin aggregation in the ER causes synaptic protein imbalance in rod photoreceptors

Samantha L. Thompson, Sophie M. Crowder, Maryam Hekmatara, Emily R. Sechrest, Wen‐Tao Deng, Michael A. Robichaux

This study investigates how mislocalized P23H rhodopsin affects synaptic protein levels in rod photoreceptors using mouse models and proteomics.

bioRxiv · Oct 18, 2024 · PreprintNeuroscience