Ken‐ichi Hironaka

This study uses mathematical modeling to show insulin selectively regulates lipid and BCAA metabolism in humans, with distinct effects on influx and efflux.

The paper introduces DI/cle, a new index combining insulin sensitivity, secretion, and clearance, showing it is impaired in T2DM but not in IGT.

This study compares hypothesis-driven and data-driven analyses using tensor decomposition on human blood metabolome data, finding that tensor decomposition can extract similar biological features more efficiently.

This study uses multiomic analysis of skeletal muscle in obese and healthy mice to reveal differences in metabolic regulation by metabolites and genes after glucose administration.

This paper introduces OMELET, a method to infer metabolic flux from multi-omic data, and applies it to identify obesity-associated dysregulation in liver glucose metabolism.

The paper analyzes trans-omic data from healthy and obese mice to reveal that glucose-responsive liver metabolism is regulated by rapid changes in metabolites and gene expression in the healthy state, and by slow transcriptional regulation in the obese state.

The paper shows that small intracellular and large intercellular variations enhance information transmission, enabling precise tissue function control.