Akiyoshi Hirayama

MassBank Human: The annotated human metabolome

The paper develops MassBank Human, a curated metabolomics resource that improves structural annotation of the human metabolome, doubling coverage in colorectal cancer cells and identifying acetylated polyamines as metabolic markers.

The Gibbs free energy landscape based on liver metabolome revealed thermodynamic robustness against fasting and obesity

The paper maps the Gibbs free energy landscape of liver metabolism in mice during fasting and obesity, revealing thermodynamic robustness despite metabolic changes.

Folate-dependent one-carbon metabolism controls meiotic and post-meiotic epigenome remodeling in the male germline

This study shows folate deficiency during spermatogenesis causes stage-specific metabolic and chromatin changes in the male germline, affecting histone modifications and epigenetic inheritance.

A sequential, RNA-derived, modified adenosine pathway safeguards cellular metabolism

The paper shows that modified adenosines from RNA catabolism are sequentially metabolized to prevent toxicity and maintain metabolic balance.

Global loss of responsiveness in key regulator metabolites and elevated enzyme proteins as metabolic dysregulation in skeletal muscle and liver of obese mice during starvation

The paper examines metabolic adaptations during starvation in obese mice, finding impaired responsiveness and elevated enzyme expression in skeletal muscle and liver.

Structural robustness and temporal vulnerability of the starvation-responsive metabolic network in liver of healthy and obese mice

The paper examines how obesity disrupts the temporally ordered metabolic network in the liver during starvation, revealing structural robustness but temporal vulnerability.

Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity

The paper compares metabolic dysregulation in obese mice during feeding and fasting using multi-omics data, revealing opposite metabolic shifts linked to obesity.

Transcriptome analysis of the tardigrade Hypsibius exemplaris exposed to the DNA-damaging agent bleomycin

This study analyzes the transcriptome of Hypsibius exemplaris exposed to bleomycin, identifying tardigrade-specific gene families and tryptophan metabolism pathway enrichment linked to stress tolerance.

In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states

This study uses multiomic analysis of skeletal muscle in obese and healthy mice to reveal differences in metabolic regulation by metabolites and genes after glucose administration.

Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism

This paper introduces OMELET, a method to infer metabolic flux from multi-omic data, and applies it to identify obesity-associated dysregulation in liver glucose metabolism.

Trans-omic analysis reveals allosteric and gene regulation-axes for altered glucose-responsive liver metabolism associated with obesity

The paper analyzes trans-omic data from healthy and obese mice to reveal that glucose-responsive liver metabolism is regulated by rapid changes in metabolites and gene expression in the healthy state, and by slow transcriptional regulation in the obese state.