The paper uses spatial proteomics to identify projection-specific molecular diversity in the prefrontal cortex and identifies BLTP2 as a key presynaptic protein involved in memory and behavior.

bioRxiv · Feb 8, 2026 · PreprintNeuroscience

Non-invasive optical synthetization of hearing sensation in non-genetically modified animal

Yuta Tamai, Miku Uenaka, Aya Okamoto, Keito Hosokawa, Yuki Ito, Koji Toda, Shizuko Hiryu, Kohta I. Kobayasi

This study shows that infrared laser stimulation of the cochlea can elicit and enhance auditory perception in gerbils, comparable to sound stimuli, and can be used to improve auditory prostheses.

bioRxiv · May 13, 2023 · PreprintNeuroscience

In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states

Toshiya Kokaji, Miki Eto, Atsushi Hatano, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken‐ichi Hironaka, Yuki Ito, Riku Egami, Saori Uematsu, Akira Terakawa, Yifei Pan, Hideki Maehara, Dongzi Li, , Shinya Kuroda

This study uses multiomic analysis of skeletal muscle in obese and healthy mice to reveal differences in metabolic regulation by metabolites and genes after glucose administration.

Scientific Reports · Aug 12, 2022Peer-reviewedSystems Biology

Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism

Saori Uematsu, Satoshi Ohno, Kaori Y. Tanaka, Atsushi Hatano, Toshiya Kokaji, Yuki Ito, Hiroyuki Kubota, Ken‐ichi Hironaka, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda

This paper introduces OMELET, a method to infer metabolic flux from multi-omic data, and applies it to identify obesity-associated dysregulation in liver glucose metabolism.

iScience · Feb 1, 2022Peer-reviewedSystems Biology

Trans-omic analysis reveals allosteric and gene regulation-axes for altered glucose-responsive liver metabolism associated with obesity

Toshiya Kokaji, Atsushi Hatano, Yuki Ito, Katsuyuki Yugi, Miki Eto, Satoshi Ohno, Masashi Fujii, Ken‐ichi Hironaka, Riku Egami, Hiroshi Inoue, Shinsuke Uda, Hiroyuki Kubota, Yutaka Suzuki, Kazutaka Ikeda, Makoto Arita, , Shinya Kuroda

The paper analyzes trans-omic data from healthy and obese mice to reveal that glucose-responsive liver metabolism is regulated by rapid changes in metabolites and gene expression in the healthy state, and by slow transcriptional regulation in the obese state.

bioRxiv · May 31, 2019 · PreprintSystems Biology