Dirk R. Albrecht

The paper develops a mathematical framework to explain how neural adaptation in C. elegans leads to flexible behavioral responses, including habituation and paradoxical inversion.

The paper develops methods to analyze sleep and neural activity in adult C. elegans, finding that sleep increases arousal threshold without altering sensory neuron responses.

This study shows that genetic sex modulates a shared chemosensory circuit in C. elegans, altering behavioral responses to sex pheromones through a cell-autonomous switch in the ADF neuron.