Brianna Fernandez

Single-cell RNA sequencing reveals distinct senotypes and a quiescence-senescence continuum at the transcriptome level following chemotherapy

The paper uses single-cell RNA sequencing and time-lapse imaging to distinguish quiescence and senescence after chemotherapy, revealing a continuum of cell-cycle withdrawal.

p16 expression confers sensitivity to CDK2 inhibitors

The paper shows that p16 expression in ovarian cancers increases sensitivity to CDK2 inhibitors by inhibiting CDK4/6, suggesting p16 as a biomarker for CDK2 inhibitor response.

The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal

The study shows that senescence biomarker intensities reflect the duration of cell-cycle withdrawal, suggesting quiescence and senescence are part of a continuum.

Response to Polygenic Risk: Results of the MyGeneRank Mobile Application-Based Coronary Artery Disease Study

This study evaluates the impact of coronary artery disease polygenic risk scores on lipid-lowering therapy initiation via a mobile application, finding higher therapy rates among high-risk individuals.

CRISPR-Cas-mediated tethering recruits the yeast HMR mating-type locus to the nuclear periphery but fails to silence gene expression

This study shows that CRISPR-Cas-mediated tethering recruits the yeast HMR locus to the nuclear periphery but does not silence gene expression, unlike a Gal4-mediated system.