Olga Lanzetta

This study identifies regulatory sequences of the Tbx1 gene and shows their deletion disrupts cardiopharyngeal lineage specification and embryonic patterning, leading to pharyngeal defects.

The paper investigates the role of Tbx1 in cardiopharyngeal mesoderm differentiation and morphogenesis, finding it stabilizes transcriptional profiles and regulates a conserved gene module.

The paper identifies endothelial regulatory elements associated with cardiopharyngeal lineage differentiation using chromatin remodeling data, gene expression, and machine learning.

The paper shows that Minoxidil treatment reduces cardiac outflow tract septation defects in a Tbx1 mutant mouse model of DiGeorge syndrome by inhibiting collagen cross-linking.