Katharina Jechow

Latent plasticity of the human pancreas across development, health, and disease.

The paper constructs a single-cell multiomics atlas of the human pancreas across development, health, and T2D, identifying plastic cell states and lineage trajectories.

Long-read single-cell RNA sequencing uncovers cell-type specific transcript regulation in COVID-19

This study uses long-read single-cell RNA sequencing to identify cell-type specific alternative splicing changes in COVID-19 patients compared to healthy controls.

Tbx1 stabilizes differentiation of the cardiopharyngeal mesoderm and drives morphogenesis in the pharyngeal apparatus

The paper investigates the role of Tbx1 in cardiopharyngeal mesoderm differentiation and morphogenesis, finding it stabilizes transcriptional profiles and regulates a conserved gene module.

ELF5 is a respiratory epithelial cell-specific risk gene for severe COVID-19

This study identifies ELF5 as a risk gene for severe COVID-19 using genetic and single-cell expression data, showing its specific expression in respiratory epithelial cells.

Profibrotic priming of airway cell types and drug responses in early-stage idiopathic pulmonary fibrosis

This study uses early-stage IPF patient-derived cells to identify proinflammatory and fibrotic states and assess drug responses in airway cells.

Unraveling mitotic protein networks by 3D multiplexed epitope drug screening

This paper introduces 3D SPECS, a method to map spatial protein localization in 3D cell cultures and analyze mitotic protein networks, revealing novel insights into spindle fragility and chromatin stress.