Connor C. Fausto

Axial Nephron Fate Switching Demonstrates a Plastic System Tunable on Demand

The paper demonstrates that human nephron cells can switch between proximal and distal identities through WNT, FGF, and BMP signaling, showing developmental plasticity.

Defining and Controlling Axial Nephron Patterning in Human Kidney Organoids with Synthetic Wnt-Secreting Organizers

This study defines axial nephron patterning in human kidney organoids by using synthetic Wnt-secreting organizers to mimic developmental signals and achieve in vivo-like polarity.

Stepwise developmental mimicry generates proximal-biased kidney organoids

This paper develops a method to generate proximal tubule precursor cells in kidney organoids using transient Notch signaling activation, showing functional maturity and injury response.