Author

Alan Sher

National Institutes of HealthORCID 0000-0001-7053-2895Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Addis Yilma· 1 shared Andrew Jesse GarciaiD· 1 shared Bernard A. P. LafontiD· 1 shared Carl G. FengiD· 1 shared Chad S. ClancyiD· 1 shared Danielle O’MardiD· 1 shared Darla QuijadaiD· 1 shared Diego Luís CostaiD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

Addis Yilma

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2 papers

Recent·Most cited

MicrobiologyAntimicrobial Agents and ChemotherapyPeer-reviewedDec 22, 2023

The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model

Jennie Ruelas Castillo, Pranita Neupane, Styliani Karanika…·Petros C. Karakousis

This paper evaluates the adjunctive effect of the HO-1 inhibitor stannsoporfin in combination with a novel MDR-TB regimen in a murine model, showing reduced lung bacillary burden but no effect on microbiological relapse.

7 citations

mousebulk RNA-seq

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ImmunologyNature CommunicationsPeer-reviewedDec 12, 2023

Pre-existing interferon gamma conditions the lung to mediate early control of SARS-CoV-2

Kerry L. Hilligan, Sivaranjani Namasivayam, Chad S. Clancy…·Alan Sher

This study shows that pre-existing IFN-gamma responses from bacterial infection reduce SARS-CoV-2 viral loads in the lungs and protect against disease in mice.

60 citationstop 2%

mouseexperimental assay

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