Petros C. Karakousis

This study identifies blood-based biomarkers that predict early tuberculosis culture conversion by analyzing mRNA and small RNA changes during treatment.

This study identifies the phosphate transport gene pstA1 as a key contributor to rifampin tolerance in Mycobacterium tuberculosis, showing that its deletion reduces bacterial survival during antibiotic treatment.

A DNA vaccine targeting Mtb persisters reduces TB treatment duration in mice and elicits similar immune responses in macaques.

This study shows that an intranasal DNA vaccine targeting RelMtb with MIP3α induces T-cell infiltration in the lungs of mice and macaques, enhancing immune responses against Mtb.

This study shows that targeting CCRL2 with an antibody-drug conjugate improves TB treatment in mice by reducing inflammation and enhancing immune responses.

This study evaluates two compounds that reduce triglyceride content in Mtb-infected macrophages but finds they do not reduce bacterial burden or inflammation in infected mice.