Linda R. Klei

This study shows that inhibiting MALT1 protease in glioblastoma-associated macrophages reduces immunosuppression and tumor growth by reprogramming macrophages to an M1-like phenotype.

The paper develops a novel mouse cell line model of invasive lobular breast carcinoma that recapitulates human tumor phenotype and immune microenvironment, offering a preclinical platform for therapy evaluation.

This study shows that chronic inflammation and hormonal changes in older women create a tumor-permissive environment for ER+ breast cancer by increasing local estradiol and immune dysfunction.