Samantha Caldwell

The paper shows cancer cells in the lung take up cysteine and cystine efficiently, and the reduced tumor microenvironment supports their growth and resistance to oxidative stress.

The paper introduces an anesthesia-free infusion technique for in vivo metabolic tracing in mice, achieving steady-state labeling comparable to jugular infusion without excessive cystine accumulation.

This study identifies PHGDH as a driver of PDAC progression by maintaining glutamine metabolism and mTOR signaling, revealing a therapeutic vulnerability to glutamine antagonism in PHGDH-deficient tumors.